Int J Biol Sci. 2009 Nov 26;5(7):758-62.

Physiological and oncogenic Aurora-A pathway.

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Department of Breast Oncology, Saitama Medical School, Japan.

Abstract

Aurora family of protein kinases have emerged as crucial factors of, not only mitosis and cytokinesis, but also human carcinogenesis. Among these family members is Aurora-A that is frequently overexpressed in varieties of human cancer. Both in vitro and in vivo studies demonstrated that Aurora-A induces tumorigenesis through genome instability. These studies have further shown that cell signaling cross-talk between Aurora-A and other cellular proteins are essential for fully-transformed phenotypes. This review summarizes recent progress of Aurora-A-associated carcinogenesis.

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Physiological and oncogenic Aurora-A pathway.

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