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Int J Gynecol Cancer. 2009 Nov;19(8):1300-2. doi: 10.1111/IGC.0b013e3181b9fa5d.

CYP1A1 and CYP2D6 gene polymorphisms in Israeli Jewish women with cervical cancer.

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  • 1Department of Obstetrics and Gynecology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel.

Abstract

HYPOTHESIS:

To assess the frequency distribution of the CYP1A1 and CYP2D6 gene polymorphisms in Israeli Jewish women with cervical cancer.

METHODS:

Forty-three Israeli Jewish women with cervical cancer and 123 healthy Israeli Jewish women were assessed. CYP1A1 (2 alleles) and CYP2D6 polymorphism was analyzed using an allele-specific, polymerase chain reaction-based method.

RESULTS:

The allele frequency and genotype distribution for the CYP1A1 (2 alleles) and CYP2D6 polymorphism did not reach a level of significance. Smoking was the only independent risk factor for cervical cancer (P = 0.0003).

CONCLUSION:

CYP1A1 and CYP2D6 mutations are not related to an increased risk for cervical cancer in the Jewish Israeli population.

[PubMed - indexed for MEDLINE]
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