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Sci Signal. 2009 Dec 15;2(101):pe78. doi: 10.1126/scisignal.2101pe78.

Cell mechanics and feedback regulation of actomyosin networks.

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  • 1Howard Hughes Medical Institute and the Developmental Biology Program, Sloan-Kettering Institute, 1275 York Avenue, New York, NY 10065, USA.


Actomyosin contractility is the major force-generating machinery that shapes cells and tissues during morphogenesis. New evidence from Drosophila demonstrates that these forces are spatially organized by a combination of biochemical and mechanical signals that provide dynamic feedback in a complex cellular environment.

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