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J Mol Cell Biol. 2010 Jun;2(3):105-6. doi: 10.1093/jmcb/mjp047. Epub 2009 Dec 14.

A G-coupled receptor protein critical for peripheral nerve myelination.

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  • 1The Jack Miller Center for Peripheral Neuropathy, Department of Neurology, The University of Chicago, 5841 South Maryland Avenue, MC2030, Chicago, IL 60637, USA.


Intercellular signaling between the axon and myelinating glial cells plays an essential role in the regulation of the myelination process. A recent study from Monk et al. has used a forward genetics approach in zebrafish to identify a G protein-coupled receptor that is necessary for Schwann cells to myelinate axons, thereby uncovering a critical component of the axo-glial signaling network.

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