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J Exp Med. 2009 Dec 21;206(13):3115-30. doi: 10.1084/jem.20091756. Epub 2009 Dec 14.

The origin and development of nonlymphoid tissue CD103+ DCs.

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  • 1Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.

Abstract

CD103(+) dendritic cells (DCs) in nonlymphoid tissues are specialized in the cross-presentation of cell-associated antigens. However, little is known about the mechanisms that regulate the development of these cells. We show that two populations of CD11c(+)MHCII(+) cells separated on the basis of CD103 and CD11b expression coexist in most nonlymphoid tissues with the exception of the lamina propria. CD103(+) DCs are related to lymphoid organ CD8(+) DCs in that they are derived exclusively from pre-DCs under the control of fms-like tyrosine kinase 3 (Flt3) ligand, inhibitor of DNA protein 2 (Id2), and IFN regulatory protein 8 (IRF8). In contrast, lamina propria CD103(+) DCs express CD11b and develop independently of Id2 and IRF8. The other population of CD11c(+)MHCII(+) cells in tissues, which is CD103(-)CD11b(+), is heterogenous and depends on both Flt3 and MCSF-R. Our results reveal that nonlymphoid tissue CD103(+) DCs and lymphoid organ CD8(+) DCs derive from the same precursor and follow a related differentiation program.

PMID:
20008528
[PubMed - indexed for MEDLINE]
PMCID:
PMC2806447
Free PMC Article
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