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J Exp Med. 2009 Dec 21;206(13):2865-8. doi: 10.1084/jem.20092533. Epub 2009 Dec 14.

Mincle is a long sought receptor for mycobacterial cord factor.

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  • 1Laboratory of Cell Regulation, Department of Viral Oncology, Institute for Virus Research, Kyoto University, Sakyo-ku Kyoto 606-8507, Japan.


Mycobacterium tuberculosis is a leading killer worldwide, yet the adjuvancy of its cell wall has proven to be a valuable therapeutic tool for vaccination and immunotherapy. Much research effort has focused on the mycobacterial glycolipid trehalose-6,6'-dimycolate (TDM), a potent immunostimulant that is also known as cord factor. Now, the identification of the monocyte-inducible C-type lectin (Mincle) as an essential receptor for TDM provides new insight into the formation of the characteristic granulomas in tuberculosis and an avenue for rational adjuvant design.

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