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Brief Funct Genomics. 2010 Jan;9(1):4-12. doi: 10.1093/bfgp/elp049. Epub 2009 Dec 13.

Gene-centered regulatory networks.

Author information

  • 1Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01605, USA. marian.walhout@umassmed.edu

Abstract

Differential gene expression plays a critical role in the development and physiology of multicellular organisms. At a 'systems level' (e.g. at the level of a tissue, organ or whole organism), this process can be studied using gene regulatory network (GRN) models that capture physical and regulatory interactions between genes and their regulators. In the past years, significant progress has been made toward the mapping of GRNs using a variety of experimental and computational approaches. Here, we will discuss gene-centered approaches that we employed to characterize GRNs and describe insights that we have obtained into the global design principles of gene regulation in complex metazoan systems.

PMID:
20008400
[PubMed - indexed for MEDLINE]
PMCID:
PMC3096532
Free PMC Article

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