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J Mol Cell Biol. 2010 Apr;2(2):70-3. doi: 10.1093/jmcb/mjp040. Epub 2009 Dec 11.

Destruction of a destructor: a new avenue for cancer therapeutics targeting the Wnt pathway.

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  • 1Department of Molecular and Cellular Biochemistry, Markey Cancer Center, University of Kentucky, Lexington, KY 40506, USA.

Abstract

A new study in Nature has identified a small molecule inhibitor for the oncogenic Wnt/beta-catenin pathway that is responsible for many human cancers. This inhibitor targets an unsuspected cellular enzyme, Tankyrase, which controls the destruction of a beta-catenin destructor.

PMID:
20008332
[PubMed - indexed for MEDLINE]
PMCID:
PMC2861491
Free PMC Article

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