Am J Clin Nutr. 1991 Mar;53(3):702-22.

Can vitamin E protect humans against the pathological effects of ozone in smog?

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Biodynamics Institute, Louisiana State University, Baton Rouge 70803-1800.

Abstract

Ozone reacts with polyunsaturated fatty acids (PUFAs) in vitro to form free radicals, and vitamin E slows or prevents this reaction. Consistent with this, dietary vitamin E significantly protects animals against the deleterious effects of ozone and the absence of vitamin E potentiates damage by ozone. Thus, chemical and animal studies as well as the opposite effects of ozone and vitamin E on the immune system suggest the hypothesis that vitamin E can protect humans against the harmful effects of chronic exposures to ozone. However, because most humans are not vitamin E deficient, the more relevant question is whether amounts of vitamin E above the minimum of dietary requirement provide increased protection. The need for and design of further studies to answer this question are discussed.

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