Hematology Am Soc Hematol Educ Program. 2009:532-41. doi: 10.1182/asheducation-2009.1.532.

The incidence, natural history, biology, and treatment of transformed lymphomas.

Source

James P. Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA. steven_bernstein@urmc.rochester.edu

Abstract

Treatment of patients with transformed lymphoma presents a significant challenge to the practicing physician. Indeed, the transformation of follicular lymphoma to a more aggressive histology is inherent to the biology of this disease and is often associated with an aggressive clinical course, resulting in a poor prognosis. Recent population-based studies have better defined the incidence of this event, and recent laboratory studies have defined the molecular and immunological processes associated with transformation. These studies will be discussed in this review, as will the treatment options for these patients.

PMID:: 20008238; [PubMed - indexed for MEDLINE]

Free full text

LinkOut - more resources

Full Text Sources

HighWire

Medical

Lymphoma - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Long-term follow-up of autologous stem-cell transplantation for follicular and transformed follicular lymphoma. [Eur J Haematol. 2000]
Long-term follow-up of autologous stem-cell transplantation for follicular and transformed follicular lymphoma.
Berglund A, Enblad G, Carlson K, Glimelius B, Hagberg H. Eur J Haematol. 2000 Jul; 65(1):17-22.
High-dose therapy and autologous stem-cell support for chemosensitive transformed low-grade follicular non-Hodgkin's lymphoma: a case-matched study from the European Bone Marrow Transplant Registry. [J Clin Oncol. 2001]
High-dose therapy and autologous stem-cell support for chemosensitive transformed low-grade follicular non-Hodgkin's lymphoma: a case-matched study from the European Bone Marrow Transplant Registry.
Williams CD, Harrison CN, Lister TA, Norton AJ, Blystad AK, Coiffier B, Taghipour G, Schmitz N, Goldstone AH, European Bone Marrow Transplant Lymphoma Working Party. J Clin Oncol. 2001 Feb 1; 19(3):727-35.
Review Rituximab: a review of its use in non-Hodgkin's lymphoma and chronic lymphocytic leukaemia. [Drugs. 2003]
Review Rituximab: a review of its use in non-Hodgkin's lymphoma and chronic lymphocytic leukaemia.
Plosker GL, Figgitt DP. Drugs. 2003; 63(8):803-43.
Review Treatment of relapsed aggressive lymphomas: regimens with and without high-dose therapy and stem cell rescue. [Cancer Chemother Pharmacol. 2002]
Review Treatment of relapsed aggressive lymphomas: regimens with and without high-dose therapy and stem cell rescue.
Hagemeister FB. Cancer Chemother Pharmacol. 2002 May; 49 Suppl 1:S13-20. Epub 2002 Apr 12.
Review Radioimmunotherapy for stem cell transplantation in non-Hodgkin's lymphoma: in pursuit of a complete response. [Oncologist. 2009]
Review Radioimmunotherapy for stem cell transplantation in non-Hodgkin's lymphoma: in pursuit of a complete response.
Gisselbrecht C, Vose J, Nademanee A, Gianni AM, Nagler A. Oncologist. 2009; 14 Suppl 2:41-51.

See reviews... See all...

Cited by 2 PubMed Central articles

High-dose therapy and autologous stem cell transplant for transformed non-Hodgkin lymphoma in the rituximab era. [Leuk Lymphoma. 2012]
High-dose therapy and autologous stem cell transplant for transformed non-Hodgkin lymphoma in the rituximab era.
Ban-Hoefen M, Kelly JL, Bernstein SH, Liesveld J, Constine L, Becker M, Milner L, Phillips G, Friedberg JW. Leuk Lymphoma. 2012 May; 53(5):830-5. Epub 2011 Dec 6.
Review Treatment options for transformed lymphoma: incorporating allogeneic stem cell transplantation in a multimodality approach. [Biol Blood Marrow Transplant. ...]
Review Treatment options for transformed lymphoma: incorporating allogeneic stem cell transplantation in a multimodality approach.
Reddy N, Savani BN. Biol Blood Marrow Transplant. 2011 Sep; 17(9):1265-72. Epub 2011 May 11.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The incidence, natural history, biology, and treatment of transformed lymphomas.
The incidence, natural history, biology, and treatment of transformed lymphomas.
Hematology Am Soc Hematol Educ Program. 2009 :532-41. doi: 10.1182/asheducation-2009.1.532.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

The incidence, natural history, biology, and treatment of transformed lymphomas.

Source

Abstract

Publication Types, MeSH Terms

Publication Types

MeSH Terms

LinkOut - more resources

Full Text Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Cited by 2 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information