Science. 2009 Dec 11;326(5959):1533-7. doi: 10.1126/science.1178250.

An analytical solution to the kinetics of breakable filament assembly.

Knowles TP, Waudby CA, Devlin GL, Cohen SI, Aguzzi A, Vendruscolo M, Terentjev EM, Welland ME, Dobson CM.

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Cavendish Laboratory, University of Cambridge, J. J. Thomson Avenue, Cambridge CB3 0HE, UK.

Abstract

We present an analytical treatment of a set of coupled kinetic equations that governs the self-assembly of filamentous molecular structures. Application to the case of protein aggregation demonstrates that the kinetics of amyloid growth can often be dominated by secondary rather than by primary nucleation events. Our results further reveal a range of general features of the growth kinetics of fragmenting filamentous structures, including the existence of generic scaling laws that provide mechanistic information in contexts ranging from in vitro amyloid growth to the in vivo development of mammalian prion diseases.

PMID:: 20007899; [PubMed - indexed for MEDLINE]

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An analytical solution to the kinetics of breakable filament assembly.
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Science. 2009 Dec 11 ;326(5959):1533-7. doi: 10.1126/science.1178250.

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