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Clin Neurophysiol. 2010 Mar;121(3):332-9. doi: 10.1016/j.clinph.2009.10.035. Epub 2009 Dec 16.

Differences in TMS-evoked responses between schizophrenia patients and healthy controls can be observed without a dedicated EEG system.

Author information

  • 1Department of Physics of Complex Systems, The Weizmann Institute of Science, Rehovot, Israel. navalb@idc.ac.il

Abstract

OBJECTIVE:

The combination of transcranial magnetic stimulation (TMS) and electroencephalography (EEG) has been hampered by the large artifact that the TMS generates in the EEG. Using TMS with EEG necessitates a sophisticated artifact-resistant EEG system that can acquire reliable signals in the crucial several tens of milliseconds immediately following the TMS pulse. Here, we demonstrate the use of a novel artifact removal algorithm together with a 24-bit EEG system to achieve similar recordings as those obtained with the dedicated TMS-compatible EEG system.

METHODS:

This setup was used to compare TMS-evoked responses between a group of healthy controls and a group of patients with schizophrenia, a condition in which effective neural connectivity is thought to be compromised.

RESULTS:

We observe differences in TMS-evoked responses between the two groups, similar to those recently reported in a study that used a dedicated TMS-compatible EEG system.

CONCLUSIONS:

The standard 24-bit EEG system combined with an artifact removal algorithm produces results similar to the dedicated TMS-compatible system.

SIGNIFICANCE:

This paves the way for more researchers and clinicians to use TMS-evoked responses for research and diagnosis of a wide spectrum of disorders.

PMID:
20006543
[PubMed - indexed for MEDLINE]
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