Am J Emerg Med. 2010 Jan;28(1):95-102.

Termination of drug-induced torsades de pointes with overdrive pacing.

Charlton NP, Lawrence DT, Brady WJ, Kirk MA, Holstege CP.

Source

Department of Emergency Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.

Abstract

Drug-induced prolongation of the QT interval is frequently encountered after medication overdose. Such toxicity can result in degeneration to torsades de pointes (TdP) and require overdrive pacing. We present 3 cases in which intentional medication overdose resulted in QTc prolongation with subsequent degeneration to TdP. Despite appropriate care, including magnesium therapy, each case required overdrive pacing for resolution of TdP. Although rarely encountered, patients with drug-induced TdP can be successfully managed with overdrive pacing.

PMID:: 20006210; [PubMed - indexed for MEDLINE]

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Life-threatening ventricular arrhythmia (torsades de pointes) after haloperidol overdose. [Hum Exp Toxicol. 1991]
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