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Mol Cell. 2009 Dec 11;36(5):715-9. doi: 10.1016/j.molcel.2009.11.030.

Reverse transcribing the code for chromosome stability.

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  • 1Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. sartandi@stanford.edu


The linearity of eukaryotic chromosomes presents challenges to cells, as the presence of DNA "ends" poses problems for the DNA replication machinery and the cell's damage response systems. This year's Nobel Prize in Physiology or Medicine recognized groundbreaking studies establishing the telomere field as a crucial area of biomedical research.

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