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Expert Opin Ther Targets. 2010 Jan;14(1):21-9. doi: 10.1517/14728220903449244.

Targeting the TNF-alpha pathway in sarcoidosis.

Author information

  • 1Pulmonary Disease University Hospital, 700115 Iasi, Romania. sabina.antonela.antoniu@pneum.umfiasi.ro

Abstract

IMPORTANCE OF THE FIELD/SIGNIFICANCE: Sarcoidosis is a granulomatous disease with various organ manifestations in which TNF-alpha has been demonstrated to play a major pathogenic role. The existing conventional therapies are not always able to minimize TNF-alpha-driven inflammation and other approaches should be used.

AREAS COVERED IN THIS REVIEW:

TNF-alpha roles in sarcoid inflammation and granuloma formation are reviewed based on the literature published in the last two decades and the therapies able to target it specifically or non-specifically in sarcoidosis are discussed.

WHAT THE READER WILL GAIN:

A better understanding of the pathogenic role of TNF-alpha in sarcoidosis and of the scientific rationale of its therapeutic blockade.

TAKE HOME MESSAGE:

In some subsets of sarcoidosis with more rapid progession and/or therapeutic refractoriness TNF-alpha plays a more prominent role in disease pathogenesis, and its blockade might represent an appropriate therapeutic approach.

PMID:
20001207
[PubMed - indexed for MEDLINE]
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