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Eur Arch Psychiatry Clin Neurosci. 2010 Sep;260(6):499-506. doi: 10.1007/s00406-009-0093-2. Epub 2009 Dec 9.

The role of proteomics in depression research.

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  • 1Max Planck Institute for Psychiatry, Kraepelinstr. 2, 80804, Munich, Germany.


Depression is a severe neuropsychiatric disorder affecting approximately 10% of the world population. Despite this, the molecular mechanisms underlying the disorder are still not understood. Novel technologies such as proteomic-based platforms are beginning to offer new insights into this devastating illness, beyond those provided by the standard targeted methodologies. Here, we will show the potential of proteome analyses as a tool to elucidate the pathophysiological mechanisms of depression as well as the discovery of potential diagnostic, therapeutic and disease course biomarkers.

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