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Am J Surg. 2009 Dec;198(6):792-7. doi: 10.1016/j.amjsurg.2009.04.026.

Is excisional biopsy indicated for patients with lobular neoplasia diagnosed on percutaneous core needle biopsy of the breast?

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  • 1Department of Surgery, Mayo Clinic, 5777 E. Mayo Boulevard, Phoenix, AZ 85054, USA.

Abstract

BACKGROUND:

The value of excisional biopsy for patients with lobular neoplasia diagnosed by core needle breast biopsy is controversial.

METHODS:

A retrospective analysis of all patients with lobular carcinoma in situ or atypical lobular hyperplasia on core needle biopsy.

RESULTS:

Twenty-five patients were identified. Twelve (48%) underwent excisional biopsy. None of the patients who had excisional biopsy were found to have ductal carcinoma in situ (DCIS) or invasive cancer. The mean follow-up was 66 months. Five patients (20%) developed DCIS or invasive cancer during follow-up. The rate of subsequent carcinoma among those undergoing excisional biopsy was 25%, and among those not undergoing excisional biopsy it was 15% (P = .57). Among patients who did not undergo excisional biopsy, none developed carcinoma within the same quadrant of the breast.

CONCLUSIONS:

Excisional biopsy for lobular neoplasia did not identify understaged carcinoma or alter the rate of subsequent carcinoma. The subsequent carcinoma risk is diffuse and bilateral; it does not correlate with the site at which lobular neoplasia was diagnosed.

PMID:
19969131
[PubMed - indexed for MEDLINE]
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