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Clin Interv Aging. 2009;4:445-9. Epub 2009 Nov 18.

Reducing hip fracture risk with risedronate in elderly women with established osteoporosis.

Author information

  • 1Nottingham University Hospitals NHS Trust, Nottingham, UK. tahir.masud@nuh.nhs.uk

Abstract

BACKGROUND:

There is limited evidence to support the efficacy of current pharmaceutical agents in reducing the risk of hip fracture in older postmenopausal women with established osteoporosis.

OBJECTIVE:

To clarify the efficacy of risedronate in reducing the risk of hip fracture in elderly postmenopausal women aged > or = 70 years with established osteoporosis, i.e., those with bone mineral density-defined osteoporosis and a prevalent vertebral fracture.

METHODS:

Post hoc analysis of the Hip Intervention Program (HIP) study, a randomized controlled trial comparing risedronate with placebo for reducing the risk of hip fracture in elderly women. Women aged 70 to 100 years with established osteoporosis (baseline femoral neck T-score < or = -2.5 and > or =1 prior vertebral fracture) were included. The main outcome measure was 3-year hip fracture incidence in the risedronate and placebo groups.

RESULTS:

A total of 1656 women met the inclusion criteria. After 3 years, hip fracture had occurred in 3.8% of risedronate-treated patients and 7.4% of placebo-treated patients (relative risk 0.54; 95% confidence interval 0.32-0.91; P = 0.019).

CONCLUSION:

Risedronate significantly reduced the risk of hip fracture in women aged up to 100 years with established osteoporosis.

KEYWORDS:

hip fracture; osteoporosis; postmenopausal; risedronate

PMID:
19966913
[PubMed - indexed for MEDLINE]
PMCID:
PMC2785868
Free PMC Article

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