Science. 2009 Nov 27;326(5957):1206-7.

Anatomic demarcation of cells: genes to patterns.

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Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA. howchang@stanford.edu

Abstract

An organizing principle of the diverse cell types in multicellular organisms is their anatomic location. In turn, anatomic location is patterned by the positional identities of cells along developmental axes. Recent progress in functional genomics and chromatin biology illustrates how cells use specific gene expression programs to encode location. Dynamic chromatin states of key genes, notably the Hox loci, serve as the internal representation in cells of their positional identity within the animal.

PMID:: 19965461; [PubMed - indexed for MEDLINE]

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Howard Hughes Medical Institute/United States

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