Patient-specific model and dual-task performance. Representative example from one subject. A) 3D brain atlas was fit to match the patient's neuroanatomy (yellow volume – thalamus; green volume – subthalamic nucleus). B) Stereotactic locations of intra-operative microelectrode recordings (thalamic cells – yellow dots; subthalamic cells – green dots; substantia nigra cells – red dots). The DBS electrodes were positioned based on stereotactic coordinates and their anatomical locations were verified by post-operative imaging data. C) Left side clinical settings: contact 1, 3.2 V, 0.06 ms, 185 Hz. D) Left side model settings: contact 2, 2.4 V, 0.06 ms, 130 Hz. E) Right side clinical settings: contact 2, 3.2 V, 0.06 ms, 185 Hz. F) Right side model settings: contact 2, 2 V, 0.06 ms, 130 Hz. G) Results of the n-back task during dual-task condition while off DBS (filled squares), clinical parameter settings (open circles) and model defined parameter settings (open triangles). H) Results of the time within ±2 percent of the target force during single task force-tracking only (FT only) and dual-task (FT + n-back task) while off DBS, clinical parameters and model defined parameters. A cross designates a significant difference between model-derived and off DBS, an asterisk marks a significant difference between model and clinical DBS and a dash represents a significant difference between clinical DBS and off DBS.