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J Biotechnol. 2010 Feb 1;145(3):240-3. doi: 10.1016/j.jbiotec.2009.11.022. Epub 2009 Dec 4.

Hydrolase-catalyzed fast Henry reaction of nitroalkanes and aldehydes in organic media.

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  • 1Department of Chemistry, Zhejiang University, Hangzhou 310027, Zhejiang, PR China.


Nitroalkanes underwent fast additions to a variety of structurally diverse aldehydes under the catalysis of d-aminoacylase in DMSO. The influences of reaction conditions including solvents, temperature, enzyme concentration and molar ratio of substrates were systematically investigated. Seventeen products were obtained in short time with moderate to high yields. It is the first report on hydrolase-catalyzed fast Henry reaction in organic solvent.

Copyright 2009 Elsevier B.V. All rights reserved.

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