Cancer Cell. 2009 Dec 8;16(6):455-7. doi: 10.1016/j.ccr.2009.11.013.

A stiff blow from the stroma: collagen crosslinking drives tumor progression.

Source

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

Abstract

Matrix stiffness is an important microenvironmental cue that regulates cell growth, motility, and differentiation. In a recent Cell report, Weaver and colleagues implicate lysyl-oxidase-mediated collagen crosslinking as a contributor to tumor matrix stiffening, which leads to enhanced integrin signaling and invasive behavior in tumors.

PMID:: 19962663; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Medical

Cancer - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Matrix crosslinking forces tumor progression by enhancing integrin signaling. [Cell. 2009]
Matrix crosslinking forces tumor progression by enhancing integrin signaling.
Levental KR, Yu H, Kass L, Lakins JN, Egeblad M, Erler JT, Fong SF, Csiszar K, Giaccia A, Weninger W, et al. Cell. 2009 Nov 25; 139(5):891-906.
Impact of treatment on myocardial lysyl oxidase expression and collagen cross-linking in patients with heart failure. [Hypertension. 2009]
Impact of treatment on myocardial lysyl oxidase expression and collagen cross-linking in patients with heart failure.
López B, Querejeta R, González A, Beaumont J, Larman M, Díez J. Hypertension. 2009 Feb; 53(2):236-42. Epub 2008 Dec 15.
Lysyl oxidase, cellular senescence and tumor suppression. [Biosci Rep. 1997]
Lysyl oxidase, cellular senescence and tumor suppression.
Sharma R, Kramer JA, Krawetz SA. Biosci Rep. 1997 Aug; 17(4):409-14.
Review Lysyl oxidase (LOX) and hypoxia-induced metastases. [Cancer Biol Ther. 2006]
Review Lysyl oxidase (LOX) and hypoxia-induced metastases.
Sion AM, Figg WD. Cancer Biol Ther. 2006 Aug; 5(8):909-11. Epub 2006 Aug 26.
Review Biochemistry and functional significance of collagen cross-linking. [Biochem Soc Trans. 2007]
Review Biochemistry and functional significance of collagen cross-linking.
Robins SP. Biochem Soc Trans. 2007 Nov; 35(Pt 5):849-52.

See reviews... See all...

Cited by 6 PubMed Central articles

Minimization of thermodynamic costs in cancer cell invasion. [Proc Natl Acad Sci U S A. 2013]
Minimization of thermodynamic costs in cancer cell invasion.
Liu L, Duclos G, Sun B, Lee J, Wu A, Kam Y, Sontag ED, Stone HA, Sturm JC, Gatenby RA, et al. Proc Natl Acad Sci U S A. 2013 Jan 29; 110(5):1686-91. Epub 2013 Jan 14.
Review Cell-cell and cell-matrix dynamics in intraperitoneal cancer metastasis. [Cancer Metastasis Rev. 2012]
Review Cell-cell and cell-matrix dynamics in intraperitoneal cancer metastasis.
Sodek KL, Murphy KJ, Brown TJ, Ringuette MJ. Cancer Metastasis Rev. 2012 Jun; 31(1-2):397-414.
Microenvironment-centred dynamics in aggressive B-cell lymphomas. [Adv Hematol. 2012]
Microenvironment-centred dynamics in aggressive B-cell lymphomas.
Cacciatore M, Guarnotta C, Calvaruso M, Sangaletti S, Florena AM, Franco V, Colombo MP, Tripodo C. Adv Hematol. 2012; 2012:138079. Epub 2012 Feb 19.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

A stiff blow from the stroma: collagen crosslinking drives tumor progression.
A stiff blow from the stroma: collagen crosslinking drives tumor progression.
Cancer Cell. 2009 Dec 8 ;16(6):455-7. doi: 10.1016/j.ccr.2009.11.013.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: