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Cancer Cell. 2009 Dec 8;16(6):455-7. doi: 10.1016/j.ccr.2009.11.013.

A stiff blow from the stroma: collagen crosslinking drives tumor progression.

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  • 1Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.


Matrix stiffness is an important microenvironmental cue that regulates cell growth, motility, and differentiation. In a recent Cell report, Weaver and colleagues implicate lysyl-oxidase-mediated collagen crosslinking as a contributor to tumor matrix stiffening, which leads to enhanced integrin signaling and invasive behavior in tumors.

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