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Best Pract Res Clin Haematol. 2009 Dec;22(4):495-9. doi: 10.1016/j.beha.2009.08.004.

Thrombopoietin in normal and neoplastic stem cell development.

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  • 1University of California San Diego Medical Center, San Diego, CA 92103-8811, USA.


It has been known for sometime that thrombopoietin acts on megakaryocytic progenitor cells to stimulate platelet production. It has recently been discovered that it also stimulates the self-renewal and expansion of normal murine and human haematopoietic stem cells (HSCs) by acting on its cognate receptor, the product of the myeloproliferative leukaemia (c-MPL) proto-oncogene. The c-MPL receptor may also play an important role in the development of human myeloproliferative disorders, essential thrombocythemia, myelofibrosis and polycythemia vera, cooperating with the dysregulated Janus kinase JAK2V(617)F.

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