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Indian J Exp Biol. 2009 Sep;47(9):743-7.

Analgesic and anticonvulsant effects of saponin isolated from the leaves of Clerodendrum infortunatum Linn. in mice.

Author information

  • 1Natural Products Research Laboratory, Department of Pharmaceutical Chemistry, Seemanta Institute of Pharmaceutical Sciences, Jharpokharia, Mayurbhanj 757 086, Orissa, India. drdilip2003@yahoo.co.in

Abstract

Saponin (SN1) isolated from C. infortunatum leaves in doses of 30, 50, 75 and 100 mg/kg, ip provided 36.28, 60.47, 90.71, 100% protection respectively from writhing induced by 1.2% v/v acetic acid. In hot plate method, SN1 not only produced analgesia in mice but also potentiated the analgesic action of pentazocine and aspirin. The anticonvulsant activity was tested by leptazol-induced seizures. SN1 decreased the duration of seizures and gave protection in a dose dependent manner against leptazol-induced convulsions. The results suggest that saponin has significant analgesic and anticonvulsant effects.

PMID:
19957887
[PubMed - indexed for MEDLINE]
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