Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Immunol. 2010 Jan 1;184(1):344-50. doi: 10.4049/jimmunol.0901841. Epub 2009 Dec 2.

Basophils protect against reinfection with hookworms independently of mast cells and memory Th2 cells.

Author information

  • 1Institute for Immunology, University of Munich, Munich, Germany.

Abstract

Hookworms infect several hundred million people worldwide, causing malnutrition, anemia, and growth retardation. Infections generally result in a strong type 2 immune response, but the effector mechanisms that mediate worm expulsion remain poorly characterized. In this study, we determined the role of mast cells and basophils in protective immunity against the murine hookworm, Nippostrongylus Brasiliensis, during primary and secondary infection. Mast cell-deficient c-Kit(W-sh) mice had lower serum IgE levels compared with wild-type mice under steady-state conditions and after N. brasiliensis infection. Worm expulsion was delayed during primary but not during secondary infection of c-Kit(W-sh) mice, even in the absence of CD4 T cells. However, protective immunity was lost when basophils were depleted before reinfection of c-Kit(W-sh) mice. We conclude that basophils play a crucial role for worm expulsion during a memory type 2 immune response independently of mast cells and memory Th2 cells.

PMID:
19955520
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk