Format

Send to

Choose Destination
See comment in PubMed Commons below
Bioorg Med Chem Lett. 2010 Jan 1;20(1):145-8. doi: 10.1016/j.bmcl.2009.11.019. Epub 2009 Nov 12.

Oxo-bridged isomers of aza-trishomocubane sigma (sigma) receptor ligands: Synthesis, in vitro binding, and molecular modeling.

Author information

  • 1School of Chemistry, University of Sydney, NSW 2006, Australia.

Abstract

Isomeric oxo-bridged analogs of aza-trishomocubane sigma (sigma) receptor ligands were synthesized and shown to display a reduced affinity for the sigma receptor. In the case of phenethyl derivative 4, there was a concomitant introduction of high-affinity for the alpha(2C) adrenergic receptor, and moderate affinity for the dopamine transporter. Molecular modeling was undertaken to rationalize these results.

Copyright 2009 Elsevier Ltd. All rights reserved.

[PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Chemical Information

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk