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    J Nutr Biochem. 2010 Mar;21(3):171-9. doi: 10.1016/j.jnutbio.2009.08.003. Epub 2009 Dec 1.

    Antiobesity mechanisms of action of conjugated linoleic acid.

    Kennedy A, Martinez K, Schmidt S, Mandrup S, LaPoint K, McIntosh M.

    Source

    Department of Nutrition, University of North Carolina Greensboro, PO Box 26170, Greensboro, NC 27402-6170, USA.

    Abstract

    Conjugated linoleic acid (CLA), a family of fatty acids found in beef, dairy foods and dietary supplements, reduces adiposity in several animal models of obesity and some human studies. However, the isomer-specific antiobesity mechanisms of action of CLA are unclear, and its use in humans is controversial. This review will summarize in vivo and in vitro findings from the literature regarding potential mechanisms by which CLA reduces adiposity, including its impact on (a) energy metabolism, (b) adipogenesis, (c) inflammation, (d) lipid metabolism and (e) apoptosis.

    2010 Elsevier Inc. All rights reserved.

    PMID:
    19954947
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2826589
    Free PMC Article

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