Int Rev Immunol. 2009;28(6):465-86.

Modulation of gut-associated lymphoid tissue functions with genetically modified Lactococcus lactis.

Source

ActoGeniX N.V., Zwijnaarde, Belgium. Pieter.Rottiers@ActoGeniX.com

Abstract

Lactic acid bacteria are a group of taxonomically diverse, Gram-positive food-grade bacteria that have been safely consumed throughout history. The lactic acid bacterium Lactococcus lactis, well-known for its use in the manufacture of cheese, can be genetically engineered and orally formulated to deliver therapeutic proteins in the gastrointestinal tract. This review focuses on the genetic engineering of Lactococcus lactis to secrete high-quality, correctly processed bioactive molecules derived from a eukaryotic background. The therapeutic applications of these genetically modified strains are discussed, with special regards to immunomodulation.

PMID:: 19954359; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Supplemental Content

Related citations

Review Immunomodulation by genetically engineered lactic acid bacteria. [Front Biosci. 2009]
Review Immunomodulation by genetically engineered lactic acid bacteria.
Van Huynegem K, Loos M, Steidler L. Front Biosci. 2009 Jun 1; 14:4825-35. Epub 2009 Jun 1.
Review Delivery of therapeutic proteins through Lactococcus lactis. [Biotechnol Genet Eng Rev. 2006]
Review Delivery of therapeutic proteins through Lactococcus lactis.
Neirynck S, Steidler L. Biotechnol Genet Eng Rev. 2006; 22:253-66.
Biological containment of genetically modified Lactococcus lactis for intestinal delivery of human interleukin 10. [Nat Biotechnol. 2003]
Biological containment of genetically modified Lactococcus lactis for intestinal delivery of human interleukin 10.
Steidler L, Neirynck S, Huyghebaert N, Snoeck V, Vermeire A, Goddeeris B, Cox E, Remon JP, Remaut E. Nat Biotechnol. 2003 Jul; 21(7):785-9. Epub 2003 Jun 15.
Review Lactococcus lactis as a live vector for mucosal delivery of therapeutic proteins. [Hum Vaccin. 2009]
Review Lactococcus lactis as a live vector for mucosal delivery of therapeutic proteins.
Bermúdez-Humarán LG. Hum Vaccin. 2009 Apr; 5(4):264-7. Epub 2009 Apr 30.
Intracellular accumulation of trehalose protects Lactococcus lactis from freeze-drying damage and bile toxicity and increases gastric acid resistance. [Appl Environ Microbiol. 2006]
Intracellular accumulation of trehalose protects Lactococcus lactis from freeze-drying damage and bile toxicity and increases gastric acid resistance.
Termont S, Vandenbroucke K, Iserentant D, Neirynck S, Steidler L, Remaut E, Rottiers P. Appl Environ Microbiol. 2006 Dec; 72(12):7694-700. Epub 2006 Oct 6.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

Recent activity

Clear Turn Off Turn On

Modulation of gut-associated lymphoid tissue functions with genetically modified...
Modulation of gut-associated lymphoid tissue functions with genetically modified Lactococcus lactis.
Int Rev Immunol. 2009 ;28(6):465-86.

PubMed
OligoDesign: Optimal design of LNA (locked nucleic acid) oligonucleotide capture...
OligoDesign: Optimal design of LNA (locked nucleic acid) oligonucleotide capture probes for gene expression profiling.
Nucleic Acids Res. 2003 Jul 1 ;31(13):3758-62.

PubMed
Endoscopic management of an unusual foreign body in the urinary bladder leading ...
Endoscopic management of an unusual foreign body in the urinary bladder leading to intractable symptoms.
Int Urol Nephrol. 2001 ;33(2):351-2.

PubMed
Effect of physiological doses of oral vitamin B12 on plasma homocysteine: a rand...
Effect of physiological doses of oral vitamin B12 on plasma homocysteine: a randomized, placebo-controlled, double-blind trial in India.
Eur J Clin Nutr. 2010 May ;64(5):495-502. Epub 2010 Mar 10 .

PubMed
Multicenter evaluation of a new shortened peptide nucleic acid fluorescence in s...
Multicenter evaluation of a new shortened peptide nucleic acid fluorescence in situ hybridization procedure for species identification of select Gram-negative bacilli from blood cultures.
J Clin Microbiol. 2010 Jun ;48(6):2268-70. Epub 2010 Mar 31 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Modulation of gut-associated lymphoid tissue functions with genetically modified Lactococcus lactis.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Related citations

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information