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Neuroradiology. 2010 Sep;52(9):837-45. doi: 10.1007/s00234-009-0631-7. Epub 2009 Dec 2.

Intra-arterial colforsin daropate for the treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhage.

Author information

  • 1Department of Neurosurgery, Nippon Steel Yawata Memorial Hospital, Yahatahigashi-ku, Kitakyushu, Japan. suzuki.s@ns.yawata-mhp.or.jp

Abstract

INTRODUCTION:

Cerebral vasospasm (CV) remains a major cause of mortality and morbidity in patients with subarachnoid hemorrhage (SAH). Here, we examined the effectiveness and safety of intra-arterial injection of colforsin daropate hydrochloride (CDH).

METHODS:

A consecutive series of 29 patients with angiographically confirmed CV received intra-arterial CDH (IAC) therapy. Angiographic changes in spastic vessels and the cerebral circulation time (CCT) were assessed before and after IAC treatment, together with the change in clinical status.

RESULTS:

IAC treatment was performed in 53 procedures in 29 patients. Angiographic improvement was observed following all procedures (100%), and clinical improvement was observed following 36 of 42 procedures (86%) in symptomatic cases. CCT improved significantly. At the 3-month follow-up, 19 patients (66%) showed good recovery or moderate disability on the Glasgow Outcome Scale. Major adverse effects were headache and increased heart rate.

CONCLUSIONS:

IAC treatment was effective and safe for the treatment of CV after SAH.

PMID:
19953235
[PubMed - indexed for MEDLINE]
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