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    Mod Rheumatol. 2010 Apr;20(2):114-22. Epub 2009 Dec 1.

    Adenosine in fibrosis.

    Chan ES, Cronstein BN.

    Source

    Clinical and Translational Science Institute, NYU School of Medicine, 550 First Ave., New York, NY 10016, USA.

    Abstract

    Adenosine is an endogenous autocoid that regulates a multitude of bodily functions. Its anti-inflammatory actions are well known to rheumatologists since it mediates many of the anti-inflammatory effects of a number of antirheumatic drugs such as methotrexate. However, inflammatory and tissue regenerative responses are intricately linked, with wound healing being a prime example. It has only recently been appreciated that adenosine has a key role in tissue regenerative and fibrotic processes. An understanding of these processes may shed new light on potential therapeutic options in diseases such as scleroderma where tissue fibrosis features prominently.

    PMID:
    19949965
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC3129242
    Free PMC Article

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