Format

Send to:

Choose Destination
See comment in PubMed Commons below
Am J Hum Genet. 2009 Dec;85(6):823-32. doi: 10.1016/j.ajhg.2009.10.028.

Short telomeres are sufficient to cause the degenerative defects associated with aging.

Author information

  • 1Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. marmani1@jhmi.edu

Abstract

Telomerase function is critical for telomere maintenance. Mutations in telomerase components lead to telomere shortening and progressive bone marrow failure in the premature aging syndrome dyskeratosis congenita. Short telomeres are also acquired with aging, yet the role that they play in mediating age-related disease is not fully known. We generated wild-type mice that have short telomeres. In these mice, we identified hematopoietic and immune defects that resembled those present in dyskeratosis congenita patients. When mice with short telomeres were interbred, telomere length was only incrementally restored, and even several generations later, wild-type mice with short telomeres still displayed degenerative defects. Our findings implicate telomere length as a unique heritable trait that, when short, is sufficient to mediate the degenerative defects of aging, even when telomerase is wild-type.

PMID:
19944403
[PubMed - indexed for MEDLINE]
PMCID:
PMC2790562
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk