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Epidemiol Infect. 2010 Jul;138(7):1032-5. doi: 10.1017/S0950268809991269. Epub 2009 Nov 27.

Alternative risk factors of HCV infection in a rural community in China.

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  • 1Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Hong Kong.


A case-control study was conducted in Linxian, Henan Province in China to explore potential risk factors for hepatitis C virus (HCV) infection unassociated with injection drug use. One hundred and ninety-two persons (41.7% male, 95.8% aged >60 years) were recruited from an earlier cohort. Of these, 48 were HCV positive and 144 HCV negative. Residence in a plain region and 3-10 injections in a health setting per year were significantly associated with HCV in both univariate and multivariate analysis (P<0.01). In rural China, the geographic distribution of HCV infection was heterogeneous and associated with injections in a health setting, a pattern which differed from the epidemics in injection drug users in urban cities.

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