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Clin Pharmacol Ther. 2010 Jan;87(1):109-16. doi: 10.1038/clpt.2009.226. Epub 2009 Nov 25.

The pharmacogenomics of membrane transporters project: research at the interface of genomics and transporter pharmacology.

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  • 1Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California, USA.

Abstract

Since the cloning of the first membrane transporter, our understanding of the role of transporters in clinical drug disposition and response has grown enormously. In parallel, large-scale genome-wide variation studies and the emerging field of pharmacogenomics have ushered in a new understanding of variations in drug response. At the crossroads of pharmacogenomics and transporter biology is the National Institutes of Health-funded Pharmacogenomics of Membrane Transporters (PMT) project, centered at the University of California, San Francisco.

PMID:
19940846
[PubMed - indexed for MEDLINE]
PMCID:
PMC2923224
Free PMC Article

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