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Am J Sports Med. 2009 Dec;37(12):2401-10. doi: 10.1177/0363546509339915.

Collagen-platelet composite enhances biomechanical and histologic healing of the porcine anterior cruciate ligament.

Author information

  • 1Department of, Orthopaedic Surgery, Children's Hospital Boston, Boston, MA 02115, USA.

Abstract

BACKGROUND:

The anterior cruciate ligament (ACL) fails to heal after traumatic rupture. Furthermore, large-animal models have recently shown that 1-month functional ACL healing is augmented after suture repair when a bioactive scaffold is placed in the tear site.

HYPOTHESIS:

At the time of suture repair, placement of a bioactive scaffold in the ACL wound site would improve the structural properties of the tissue.

STUDY DESIGN:

Controlled laboratory study.

METHODS:

Twenty-seven knees in immature pigs underwent ACL transection and suture repair. A collagen-platelet composite (CPC) was used to supplement the repair in 14 knees. Knees were harvested at 4 weeks, 6 weeks, and 3 months. Mechanical testing and histologic analysis were performed.

RESULTS:

The addition of a CPC to a suture repair resulted in improvements in yield load and linear stiffness of the repair tissue at 3 months, as well as a significant increase in cell density. A reduction in yield load and stiffness occurred at the 6-week time point in both groups, a phase when revascularization was noted.

CONCLUSION:

The addition of a CPC to a suture repair enhanced the structural properties of the ACL, and the improvement was associated with increased cellularity within the healing ligament.

CLINICAL RELEVANCE:

The addition of a bioactive scaffold to the wound site improved the functional healing of the ACL after suture repair. The decreased repair strength during revascularization may indicate a need to protect the repair site through this period.

PMID:
19940313
[PubMed - indexed for MEDLINE]
PMCID:
PMC2856313
Free PMC Article

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