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    Semin Immunol. 2010 Apr;22(2):97-102. Epub 2009 Nov 24.

    Adjuvant activity mediated by iNKT cells.

    Fujii S, Motohashi S, Shimizu K, Nakayama T, Yoshiga Y, Taniguchi M.

    Source

    Research Unit for Cellular Immunotherapy, RIKEN Research Center for Allergy and Immunology, 1-7-22, Suehiro-cho, Tsurumi-ku, Yokohama, Japan.

    Abstract

    Invariant natural killer T (iNKT) cells have adjuvant activity due to their ability to produce large amounts of IFN-gamma, which activates other cells in innate and acquired systems, and orchestrates protective immunity. Based on these adjuvant mechanisms, we developed iNKT cell-targeted adjuvant therapy and carried out a phase I/IIa trial on advanced lung cancer patients. The patient group with increased numbers of IFN-gamma-producing cells showed prolonged survival with a median survival time of 31.9 months. Sixty percent of the patients in this group survived for more than 2 years with only a primary treatment and without tumor progression and metastasis.

    PMID:
    19939703
    [PubMed - indexed for MEDLINE]

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