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Isolation and sequence of partial cDNA clones of human L1: homology of human and rodent L1 in the cytoplasmic region.
La Jolla Cancer Research Foundation, California.
We have isolated cDNA clones coding for the human homologue of the neuronal cell adhesion molecule L1. The nucleotide sequence of the cDNA clones and the deduced primary amino acid sequence of the carboxy terminal portion of the human L1 are homologous to the corresponding sequences of mouse L1 and rat NILE glycoprotein, with an especially high sequences identity in the cytoplasmic regions of the proteins. There is also protein sequence homology with the cytoplasmic region of the Drosophila cell adhesion molecule, neuroglian. The conservation of the cytoplasmic domain argues for an important functional role for this portion of the molecule.
PMID: 1993895 [PubMed - indexed for MEDLINE]
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Cited by 2 PubMed Central articles
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Structure of a new nervous system glycoprotein, Nr-CAM, and its relationship to subgroups of neural cell adhesion molecules.
Grumet M, Mauro V, Burgoon MP, Edelman GM, Cunningham BA.
J Cell Biol. 1991 Jun; 113(6):1399-412.
[J Cell Biol. 1991]
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Structure of the axonal surface recognition molecule neurofascin and its relationship to a neural subgroup of the immunoglobulin superfamily.
Volkmer H, Hassel B, Wolff JM, Frank R, Rathjen FG.
J Cell Biol. 1992 Jul; 118(1):149-61.
[J Cell Biol. 1992]