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Psychopharmacology (Berl). 2010 Feb;208(2):201-9. doi: 10.1007/s00213-009-1719-9. Epub 2009 Nov 21.

Are attention lapses related to d-amphetamine liking?

Author information

  • 1Department of Psychology, Temple University, 1701 North 13th Street, Philadelphia, PA 19122, USA. mikemccloskey@temple.edu

Abstract

RATIONALE:

A rich literature suggests that both impulsiveness and drug-induced euphoria are risk factors for drug abuse. However, few studies have examined whether sensitivity to the euphoric effects of stimulants is related to attention lapses, a behavioral measure of inattention sometimes associated with impulsivity.

OBJECTIVE:

The aim of the study was to examine ratings of d-amphetamine drug liking among individuals with high, moderate, and low attention lapses.

METHODS:

Ninety-nine healthy volunteers were divided into three equal-sized groups based on their performance on a measure of lapses of attention. The groups, who exhibited low, medium, and high attention lapses (i.e., long reaction times) on a simple reaction time task, were compared on their subjective responses (i.e., ratings of liking and wanting more drug) after acute doses of d-amphetamine (0, 5, 10, and 20 mg).

RESULTS:

Subjects who exhibited high lapses liked 20 mg d-amphetamine less than subjects who exhibited low lapses. These subjects also tended to report smaller increases in "wanting more drug" after d-amphetamine.

CONCLUSION:

The findings suggest that participants who exhibit impaired attention may be less sensitive to stimulant-induced euphoria.

PMID:
19936714
[PubMed - indexed for MEDLINE]
PMCID:
PMC4004179
Free PMC Article

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