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Nat Rev Immunol. 2009 Dec;9(12):883-9. doi: 10.1038/nri2660.

Interplay between the TH17 and TReg cell lineages: a (co-)evolutionary perspective.

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  • 1Department of Pathology, BBRB 870, University Station, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA. cweaver@uab.edu


The origins of the adaptive immune system and the basis for its unique association with vertebrate species have been a source of considerable speculation. In light of recent advances in our understanding of the developmental and functional links between the induced regulatory T cell and T helper 17 cell lineages, and their specialized relationship to the gut, we speculate that the co-evolution of these adaptive immune pathways might have given primitive vertebrates a means to benefit from the diversification of their commensal microbiota.

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