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Vaccine. 2010 Jan 22;28(4):907-15. doi: 10.1016/j.vaccine.2009.11.002. Epub 2009 Nov 21.

B cell responses to H5 influenza HA in human subjects vaccinated with a drifted variant.

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  • 1David H. Smith Center for Vaccine Biology and Immunology, Aab Institute for Biomedical Sciences, Department of Microbiology and Immunology, Rochester, NY, USA.

Abstract

B cell responses after immunization with a drifted H5 influenza/A/Vietnam/1203/04 vaccine were characterized in the peripheral blood of human subjects primed with experimental recombinant H5 influenza A/Hong Kong/156/97 vaccine. Antibody secreting cells were assayed by ELISPOT against a panel of recombinant hemagglutinin and control proteins. Increased frequencies of H5 HA-specific antibody secreting and memory B cells could be observed within 7 days of re-vaccination. Furthermore, these responses were cross-reactive to both H5 HA variants, but not H3 or avian H6 HA strains. These observations suggest prior vaccination against H5 influenza HA induces cellular immune responses that cross-react among drifted variants, without precluding a response to new, or existing HA strains.

PMID:
19932673
[PubMed - indexed for MEDLINE]
PMCID:
PMC2814950
Free PMC Article
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