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J Vet Intern Med. 2010 Jan-Feb;24(1):179-84. doi: 10.1111/j.1939-1676.2009.0416.x.

Hypogammaglobulinemia in racing Alaskan sled dogs.

Author information

  • 1Department of Clinical Sciences, Oregon State University, 227 Magruder Hall, Corvallis, OR 97331, USA. erica.mckenzie@oregeonstate.edu

Abstract

BACKGROUND:

Serum immunoglobulin dynamics have not been studied in racing sled dogs, despite hypoglobulinemia having been reported during racing events.

HYPOTHESIS/OBJECTIVES:

Hypoglobulinemia in racing sled dogs is associated with decreases in serum IgA, IgE, IgG, and IgM concentrations during prolonged exercise.

ANIMALS:

One hundred and fifty-seven Alaskan sled dogs that successfully completed a 1,000 mile race.

METHODS:

Serum was obtained from 118 sled dogs within 1 month before the race and within 12 hours after completing the race. Serum also was obtained after 4 months of rest from 51 dogs that successfully completed the race, including 12 previously sampled dogs. Serum total protein ([TP]), albumin, and globulin ([Gl]) were measured, and serum IgA, IgE, IgG, and IgM were quantified by ELISA.

RESULTS:

The proportion of dogs with [Gl] < or = 2.2 g/dL was significantly greater immediately after racing (38 of 118 dogs, 32.2%) than before racing (21 of 118 dogs, 17.8%, P = .005). Four months after racing, [Gl] was < or = 2.2 g/dL in 23.5% (12 of 51) of dogs. [IgG] was significantly lower before (8.21 +/- 4.95 mg/mL) and immediately after (7.97 +/- 5.62) racing compared with 4 months after racing (18.88 +/- 5.76). Serum [IgM] and [IgE] were higher and [IgA] was lower before racing compared with immediately after racing.

CONCLUSIONS AND CLINICAL IMPORTANCE:

Sled dogs participating in long-distance racing have substantial decreases in [IgG] in addition to decreases in [IgM] and [IgE]. The pronounced hypogammaglobulinemia observed in a large proportion of racing sled dogs might predispose them to infectious disease.

PMID:
19925575
[PubMed - indexed for MEDLINE]
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