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New Phytol. 2010 Apr;186(1):54-62. doi: 10.1111/j.1469-8137.2009.03087.x. Epub 2009 Nov 19.

The gene balance hypothesis: implications for gene regulation, quantitative traits and evolution.

Author information

  • 1Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA. birchlerj@missouri.edu

Abstract

The gene balance hypothesis states that the stoichiometry of members of multisubunit complexes affects the function of the whole because of the kinetics and mode of assembly. Gene regulatory mechanisms also would be governed by these principles. Here, we review the impact of this concept with regard to the effects on the genetics of quantitative traits, the fate of duplication of genes following polyploidization events or segmental duplication, the basis of aneuploid syndromes, the constraints on cis and trans variation in gene regulation and the potential involvement in hybrid incompatibilities.

PMID:
19925558
[PubMed - indexed for MEDLINE]
PMCID:
PMC2858765
Free PMC Article

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