Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Autism Dev Disord. 2010 Mar;40(3):300-16. doi: 10.1007/s10803-009-0872-7.

Cerebellum, language, and cognition in autism and specific language impairment.

Author information

  • 1Center for Morphometric Analysis, Massachusetts General Hospital, Boston, MA 02114, USA.

Abstract

We performed cerebellum segmentation and parcellation on magnetic resonance images from right-handed boys, aged 6-13 years, including 22 boys with autism [16 with language impairment (ALI)], 9 boys with Specific Language Impairment (SLI), and 11 normal controls. Language-impaired groups had reversed asymmetry relative to unimpaired groups in posterior-lateral cerebellar lobule VIIIA (right side larger in unimpaired groups, left side larger in ALI and SLI), contralateral to previous findings in inferior frontal cortex language areas. Lobule VIIA Crus I was smaller in SLI than in ALI. Vermis volume, particularly anterior I-V, was decreased in language-impaired groups. Language performance test scores correlated with lobule VIIIA asymmetry and with anterior vermis volume. These findings suggest ALI and SLI subjects show abnormalities in neurodevelopment of fronto-corticocerebellar circuits that manage motor control and the processing of language, cognition, working memory, and attention.

PMID:
19924522
[PubMed - indexed for MEDLINE]
PMCID:
PMC3771698
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Springer Icon for PubMed Central
    Loading ...
    Write to the Help Desk