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Nature. 1991 Jan 31;349(6308):388-93.

Involvement of p34cdc2 in establishing the dependency of S phase on mitosis.

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  • 1Biochemistry Department, University of Oxford, UK.


Mutants of cdc2+ can disrupt the dependency of S phase on completion of the previous mitosis. By changing the state of p34cdc2 it is possible to reprogramme a cell from entering mitosis to undergoing S phase. This leads to the proposal that the cell cycle can be considered a p34cdc2 cycle, and has implications for the evolution of life cycles.

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