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Gastrointest Endosc. 2010 Feb;71(2):260-5. doi: 10.1016/j.gie.2009.08.025. Epub 2009 Nov 17.

Survival in patients with pancreatic cancer after the diagnosis of malignant ascites or liver metastases by EUS-FNA.

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  • 1Division of Gastroenterology and Hepatology, Indiana University Medical Center, Indianapolis, Indiana, USA. jodewitt@iupui.edu

Abstract

BACKGROUND:

The expected survival after the EUS-FNA diagnosis of malignant ascites or liver metastases from pancreatic cancer is not known.

OBJECTIVE:

To report overall and 1-year survival in these patients.

DESIGN:

Retrospective cohort series.

SETTING:

Tertiary referral hospital.

PATIENTS:

Consecutive subjects with newly diagnosed pancreatic cancer from June 1998 and March 2008 in whom EUS-FNA of the liver or ascitic fluid confirmed hepatic metastases or malignant ascites.

INTERVENTIONS:

Calculation of survival after diagnosis by using the Social Security Death Index.

MAIN OUTCOME MEASUREMENTS:

Survival after EUS-FNA diagnosis of stage IV pancreatic cancer.

RESULTS:

EUS-FNA identified liver metastases and malignant ascites from primary pancreatic cancer in 75 and 13 patients, respectively, and all 88 died during follow-up. For all 88 patients, the 1-year survival rate and median survival were 3.4% (95% CI, 1.1%-10.4%) and 82 days (range 2-754 days), respectively. The 1-year survival rates for those with liver metastases (4.0% [95% CI, 1.3%-12.1%]) and for those with malignant ascites (0% [95% CI, 0-24.7%]) were similar (P = 1.0). The median survival for patients with liver metastases of 83 days (range 2-754 days) was similar to that for those with malignant ascites (64 days; range 2-153 days) (P = .13). No clinical variable considered predicted survival of more than, less than, or 3 months.

LIMITATIONS:

Retrospective series with variable treatment for malignancy.

CONCLUSIONS:

In patients with pancreatic cancer, identification of malignant ascites or liver metastases by EUS-FNA is associated with a very poor prognosis.

PMID:
19922924
[PubMed - indexed for MEDLINE]
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