Drug Des Devel Ther. 2009 Feb 6;2:145-50.

Surface activity of surfactant spiked with vitamin A.

Bronshtein V, Venkatesh V, Aulakh J, Chessex P.

Source

Division of Neonatology, Children's and Women's Health Centre of British Columbia, University of British Columbia, 4480 Oak Street, Vancouver, BC, Canada.

Abstract

BACKGROUND:

Intramuscular injections of vitamin A decrease the risk of broncho-pulmonary dysplasia. Admixture of vitamin A with surfactant as a lipophilic vehicle might be a less invasive modality.

AIM:

Test physical properties of surfactant + vitamin A.

METHODS:

Miscibility and surface activity were tested in surfactant supplemented with retinyl-acetate, -palmitate, 13-cis-, or all-trans-retinoic acid.

RESULTS:

Retinol acetate (5000 IU/mL) demonstrated miscibility with surfactant when premixing with ethanol. Its surface activity was 40% lower compared to surfactant alone.

CONCLUSION:

These findings warrant preclinical studies to test whether administration of vitamin A in subjects requiring surfactant is associated with beneficial functional properties.

PMID:: 19920902; [PubMed]
PMCID:: PMC2761185

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