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    Fitoterapia. 2010 Jul;81(5):306-14. Epub 2009 Nov 14.

    Supramolecular phospholipids-polyphenolics interactions: the PHYTOSOME strategy to improve the bioavailability of phytochemicals.

    Semalty A, Semalty M, Rawat MS, Franceschi F.

    Source

    Department of Pharmaceutical Sciences, HNB Garhwal University Srinagar, Garhwal, India. semaltyajay@gmail.com

    Abstract

    The poor and/or erratic oral bioavailability of polyphenolics can be improved using the PHYTOSOME delivery system, a strategy that enhances the rate and the extent of solubilization into aqueous intestinal fluids and the capacity to cross biomembranes. Phospholipids show affinity for polyphenolics, and form supramolecular adducts having a definite stoichiometry. This article reviews the preparation and characterization of PHYTOSOME complexes and their activity in various medicinal (cardiovascular, anti-inflammatory, hepatoprotective, anticancer) and cosmetic (skin aging) realms of application.

    Copyright 2009 Elsevier B.V. All rights reserved.

    PMID:
    19919847
    [PubMed - indexed for MEDLINE]

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