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Curr Protoc Immunol. 2009 Nov;Chapter 11:Unit11.9D. doi: 10.1002/0471142735.im1109ds87.

TRAF-mediated TNFR-family signaling.

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  • 1University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.


The tumor necrosis factor (TNF) superfamily consists of a wide variety of cell-bound and secreted proteins that regulate numerous cellular processes. In particular, TNF-family proteins regulate the proliferation and death of tumor cells, as well as activated immune cells. This overview discusses the mammalian TNF receptor-associated factors (TRAFs), of which TRAF1, 2, 3, 5, and 6 have been shown to interact directly or indirectly with members of the TNF receptor superfamily. Structural features of TRAF proteins are described along with a discussion of TRAF-interacting proteins and the signaling pathways activated by the TRAF proteins. Finally, we examine the phenotypes observed in TRAF-knockout mice.

Copyright (c) 2009 John Wiley & Sons, Inc.

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