Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Wound Ostomy Continence Nurs. 2009 Nov-Dec;36(6 Suppl):S12-6. doi: 10.1097/WON.0b013e3181bfdd1a.

Collagenase Santyl ointment: a selective agent for wound debridement.

Author information

  • 1Healthpoint Ltd, Fort Worth, Texas 76107, USA. lei.shi@healthpoint.com

Abstract

Enzymatic debridement is a frequently used technique for removal of necrotic tissue from wounds. Proteases with specificity to break down the collagenous materials in necrotic tissues can achieve selective debridement, digesting denatured collagen in eschar while sparing nonnecrotic tissues. This article provides information about the selectivity of a collagenase-based debriding agent, including evidence of its safe and efficacious uses. Recent research has been conducted, investigating the chemical and biological properties of collagenase ointment, including healing in animal models, digestion power on different collagen types, cell migration activity from collagen degradation products, and compatibility with various wound dressings and metal ions. Evidence presented demonstrates that collagenase ointment is an effective, selective, and safe wound debriding agent.

PMID:
19918145
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Lippincott Williams & Wilkins
    Loading ...
    Write to the Help Desk