J Clin Endocrinol Metab. 1991 Feb;72(2):256-9.

Pituitary size in depression.

Krishnan KR, Doraiswamy PM, Lurie SN, Figiel GS, Husain MM, Boyko OB, Ellinwood EH Jr, Nemeroff CB.

Source

Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710.

Abstract

Magnetic resonance images centered at the pituitary stalk were used to measure pituitary gland size in 19 patients with major depression compared with that in age- and sex-matched controls. Depressed patients had significantly greater pituitary cross-sectional area (P = 0.0009) and volume (P = 0.007) than the controls. This difference was particularly prominent in elderly depressed patients compared to elderly controls. These results provide the first demonstration of structural alterations in the pituitary gland in major depression.

Comment in

J Clin Endocrinol Metab. 1991 Feb;72(2):253-5.

PMID:: 1991797; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Grant Support

Publication Types

Research Support, U.S. Gov't, P.H.S.

MeSH Terms

Grant Support

LinkOut - more resources

Full Text Sources

HighWire Press - PDF

Other Literature Sources

COS Scholar Universe

Supplemental Content

Save items

Related citations in PubMed

Pituitary gland volume in adolescent and young adult bipolar and unipolar depression. [Bipolar Disord. 2008]
Pituitary gland volume in adolescent and young adult bipolar and unipolar depression.
MacMaster FP, Leslie R, Rosenberg DR, Kusumakar V. Bipolar Disord. 2008 Feb; 10(1):101-4.
MRI study of the pituitary gland in adolescent depression. [J Psychiatr Res. 2004]
MRI study of the pituitary gland in adolescent depression.
MacMaster FP, Kusumakar V. J Psychiatr Res. 2004 May-Jun; 38(3):231-6.
Adrenal gland volume in major depression. Increase during the depressive episode and decrease with successful treatment. [Arch Gen Psychiatry. 1995]
Adrenal gland volume in major depression. Increase during the depressive episode and decrease with successful treatment.
Rubin RT, Phillips JJ, Sadow TF, McCracken JT. Arch Gen Psychiatry. 1995 Mar; 52(3):213-8.
Review The stress system in the human brain in depression and neurodegeneration. [Ageing Res Rev. 2005]
Review The stress system in the human brain in depression and neurodegeneration.
Swaab DF, Bao AM, Lucassen PJ. Ageing Res Rev. 2005 May; 4(2):141-94.
Review Sarcoidosis: clinical, hormonal, and magnetic resonance imaging (MRI) manifestations of hypothalamic-pituitary disease in 9 patients and review of the literature. [Medicine (Baltimore). 2007]
Review Sarcoidosis: clinical, hormonal, and magnetic resonance imaging (MRI) manifestations of hypothalamic-pituitary disease in 9 patients and review of the literature.
Bihan H, Christozova V, Dumas JL, Jomaa R, Valeyre D, Tazi A, Reach G, Krivitzky A, Cohen R. Medicine (Baltimore). 2007 Sep; 86(5):259-68.

See reviews... See all...

Cited by 5 PubMed Central articles

Neuroplasticity in mood disorders. [Dialogues Clin Neurosci. 2004]
Neuroplasticity in mood disorders.
Drevets WC. Dialogues Clin Neurosci. 2004 Jun; 6(2):199-216.
Enlargement of the Third Ventricle in affective disorders. [Indian J Psychiatry. 2003]
Enlargement of the Third Ventricle in affective disorders.
Bhadoria R, Watson D, Danson P, Ferrier IN, McAllister VI, Moore PB. Indian J Psychiatry. 2003 Jul; 45(3):147-50.
Review Risk factors for development of depression and psychosis. Glucocorticoid receptors and pituitary implications for treatment with antidepressant and glucocorticoids. [Ann N Y Acad Sci. 2009]
Review Risk factors for development of depression and psychosis. Glucocorticoid receptors and pituitary implications for treatment with antidepressant and glucocorticoids.
Pariante CM. Ann N Y Acad Sci. 2009 Oct; 1179:144-52.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Pituitary size in depression.
Pituitary size in depression.
J Clin Endocrinol Metab. 1991 Feb ;72(2):256-9.

PubMed
Aquagenic wrinkling of the palms in cystic fibrosis: comparison with controls an...
Aquagenic wrinkling of the palms in cystic fibrosis: comparison with controls and genotype-phenotype correlations.
Arch Dermatol. 2009 Nov ;145(11):1296-9.

PubMed
Benign fibroepithelial polyp arising in the bronchus: a case report and review o...
Benign fibroepithelial polyp arising in the bronchus: a case report and review of the literature.
Arch Surg. 2009 Nov ;144(11):1081-3.

PubMed
Long-term outcome associated with early repolarization on electrocardiography.
Long-term outcome associated with early repolarization on electrocardiography.
N Engl J Med. 2009 Dec 24 ;361(26):2529-37. Epub 2009 Nov 16 .

PubMed
Modulation of hexokinase association with mitochondria analyzed with quantitativ...
Modulation of hexokinase association with mitochondria analyzed with quantitative three-dimensional confocal microscopy.
J Cell Biol. 1991 Feb ;112(3):385-95.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: