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Antimicrob Agents Chemother. 2010 Feb;54(2):934-6. doi: 10.1128/AAC.01345-09. Epub 2009 Nov 16.

Panel of prototypical raltegravir-resistant infectious molecular clones in a novel integrase-deleted cloning vector.

Author information

  • 1Department of Medicine, Stanford University School of Medicine, Division of Infectious Diseases, 300 Pasteur Drive, Grant Building, Room S-146, Stanford, CA 94305, USA. ereuman@stanford.edu

Abstract

We created an HIV-1 cloning vector, pNL4.3DeltaIN, to generate recombinant infectious molecular clones for analysis of patient-derived HIV-1 integrase coding regions. Using this vector, we constructed a panel of clinically derived viruses with the canonical patterns of raltegravir resistance mutations and submitted the panel to the NIH AIDS Research and Reference Reagent Program. Investigational integrase inhibitors with activity against these clones are likely to retain activity against the most clinically relevant raltegravir-resistant variants.

PMID:
19917747
[PubMed - indexed for MEDLINE]
PMCID:
PMC2812164
Free PMC Article

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